The FysiCie will oragnise a lecture by dr. Lukas Kapitein on physics inside the cell.

Location: Minnaert 2.02

Time: 17:00-18:00 with drinks afterwards

Abstract:

Lukas Kapitein studied Physics and Astronomy at the VU University in Amsterdam, where he also received his PhD in Biophysics in 2007. His postdoctoral training in Neurobiology was at the Erasmus Medical Center. As of 2011, he works as an Assistant Professor at the Division of Cell Biology within the Department of Biology of Utrecht University. 

The Kapitein lab studies the mechanisms by which cells establish and maintain their precise shape and intracellular organization. This is important, because form and function are closely connected and cellular disorganization often leads to cellular dysfunction and disease. By combining protein engineering, optogenetics, advanced (super-resolution) microscopy techniques and mathematical modeling, we aim to obtain a mechanistic understanding of cellular organization in health and disease.

In my lecture, I will highlight two recent breakthroughs from the lab. First of all, we successfully engineered a system to control the transport and positioning of intracellular components with light (Van Bergeijk et al. Nature 2015). This allows us to directly explore the functional consequences of organelle mislocalization. In addition, we have engineered novel probes for the super-resolution imaging of microtubules, the intracellular biopolymers that serve as tracks for intracellular transport. These novel probes allow us to better resolve microtubule organization in dense cellular compartments, such as the axons and dendrites of neurons (Mikhaylova et al. Nature Communications 2015).